On 12 October 2018, Science Technology and Innovation Policy Institute (STIPI), KMUTT organized the 4th STIPI Forum at the Knowledge Exchange (KX) Building, KMUTT, Bangkok, Thailand. There were three keynote speakers, Dr.Jeong Hyop Lee from STIPI, Prof. Chaisung Lim from Miller School of MOT, Konkuk University, Korea and Dr.Supachai Vongbunyoug from Institute of field Robotics (FIBO), KMUTT. The talk covers discontinuities driven by Industry 4.0 and how Thailand should respond to these challenges. What are the opportunities in terms of new product proceed and business model if Thailand want to overcome the poor market affordability and the lack of supply capacity. There were 36 participants from public and private sectors joining this forum.